COLUMBIA, 3/25/11 (Beat Byte) -- A gene
that shares a name with a popular 1970s police show -- ADAM-12 -- may prove important in the fight against cancer, arthritis, and
thickening of the heart’s muscular walls during heart disease called cardiac
hypertrophy, Mizzou College of Veterinary Medicine researchers Alpana
Ray and Bimal Ray have discovered.
Their findings -- published
in the prestigious Proceedings of the National Academy of
Sciences (PNAS) -- include how the ADAM-12 gene might be used as part of a
treatment.
"Most of the success in cancer therapy lies in a
combination of approaches and chemotherapies," Bimal Ray said. "This could
become another piece of the puzzle that leads to the cure."
ADAM-12 is a common adult gene normally found in low
levels. It's also versatile, and may play a role in cancer metastasis.
"We know that ADAM-12 allows
cancer cells to proliferate," said Alpana Ray.
The MU team found a "repressor protein" that keeps
ADAM-12 in check under normal conditions. But during cancer, arthritis and
cardiac hypertrophy, ADAM-12 levels rise. "In tissues where ADAM-12 expression
is low, the repressor is active," Alpana Ray said. "What we don’t know is how it
actually works."
If they can manipulate the repressor protein, they may be
able to figure out why ADAM-12 gene levels increase when the three disease
states are present, which "could lead to therapeutic applications," Alpana Ray
said.
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